UV-Blocking Effect of Ophthalmic Material Containing Benzophenone

Substituent contribution to the genotoxicity of benzophenone-type UV filters.

Benzophenones (BPs) are widely used in UV filters, fragrance enhancers, and plastic additives. In this study, the genotoxicity of 14 BPs was tested using the SOS/umu assay, and the related substituent contribution was disclosed. The results of this study revealed that the major contributor to the genotoxicity of the BPs was the ortho,para-di-substitution, and the increasing hydroxy substitution...

Acute Toxicity and Ecological Risk Assessment of Benzophenone-3 (BP-3) and Benzophenone-4 (BP-4) in Ultraviolet (UV)-Filters

Ultraviolet (UV)-absorbing chemicals (UV filters) are used in personal care products for the protection of human skin and hair from damage by UV radiation. Although these substances are released into the environment in the production and consumption processes, little is known about their ecotoxicology effects. The acute toxicity and potential ecological risk of UV filters benzophenone-3 (BP-3) ...

Benzophenone-containing cholesterol surrogates: synthesis and biological evaluation.

Eight analogs of cholesterol (1) containing a benzophenone group have been synthesized as prospective photoaffinity labels for studies in cellular sterol efflux and HDL formation. Six of these compounds (4-9) have the photophore replacing different portions of the cholesterol alkyl side chain, and two (10 and 11) have it attached via nitrogen at carbon 3. The suitability of these analogs as cho...

MICROBIOLOGICAL EVALUATION OF SOME OPHTHALMIC PREPARATIONS CONTAINING DIFFERENT CONCENTRATIONS OF BENZALKONIUM CHLORIDE

Zinc sulphate and boric acid ophthalmic preparations, containing benzalkonium chloride as preservative, have been investigated against gram-negative and positive bacteria. Viability of bacteria was found after 7 days, although it was completely suppressed after 24 hours of inoculation. Zinc sulphate generally increases the antimicrobial activity of benzalkonium chloride, whereas boric acid ...

UV-blocking ZnO nanostructure anti-reflective coatings